A pandemic virus has already spread worldwide, killing almost everyone. Two brothers, Brian and Danny, along with Brian's girlfriend Bobby and Danny's friend Kate, are heading to a place called Turtle Beach where they believe they can wait for the viral pandemic to die out.

On their way there, they meet a man, Frank and his infected young daughter Jodie, and end up taking them to a place where a serum for the pandemic has been developed. Upon arrival they discover that that the serum doesn't work, and the only doctor still alive is about to commit suicide with a remaining group of infected children. Meanwhile, Bobby is accidentally infected by Jodie while trying to help her. She hides her infection from the others. They leave Frank and Jodie behind.

After this, they stop at a golf course, and though Bobby tries to prevent it, Brian kisses her. The golf course is being used as a base by a small group of armed survivalists, who capture the group. They disrobe the girls to check for infection, discover Bobby's, and send them away. Kate stresses that they will end up dead if Bobby continues to travel with them and Brian ends up leaving a weeping Bobby behind at a deserted gas station.

Brian later breaks down under the pressure of having to make all of the difficult decisions in order to keep everyone alive, and Danny discovers that his brother is also infected. At Kate's urging, he shoots Brian and burns the disease-ridden body. Afterward, Danny and Kate reach Turtle Beach and Danny realizes that, without his brother, the place that had seemed so special to them as kids is now empty. The film ends, leaving their fate uncertain.